Dystrophic Calcinosis Cutis: a rare fearsome issue of Chronic Kidney Disease

Abstract

Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs.

We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand.

Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma.

Increasing of therapy with phosphate binders and cinacalcet only, was not effective to solve cutaneous masses, that were biopsied. Histological exam revealed deposition of amorphic material with calcific component, consistent with cutaneous dystrophic calcinosis.

We further increased dialysis and therapy and we observed complete regression of masses in 2 months.

 

Key words: dystrophic calcinosis cutis, end stage renale disease, calcium-phosphate metabolism, dialysis

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