Abstract

Measuring the uremic solute clearance is an important factor in analyzing the adequacy of maintenance hemodialysis (MHD) therapy. Conventionally hemodialysis (HD) adequacy was measured by urea removal through the Daugirdas single pool kt/V (spKt/V) formula. We aimed in our study to correlate online clearance monitoring (OCM) spKt/V to the Urea Reduction Ratio (URR) and Daugirdas spKt/V in maintenance hemodialysis patients. This single-center cross-sectional study, conducted at the hemodialysis unit in the nephrology department of SRM Medical College Hospital and Research Center, involved 100 participants undergoing maintenance hemodialysis (MHD) therapy for 200 sessions. The OCM with URR and Daugirdas spKt/V values were obtained from each session and the results were analyzed using SPSS software with p <0.05 significance. In the results, we found that the OCM spKt/V, Daugirdas spKt/V, and URR showed positive correlations. These results emphasize that OCM can be an alternative method to assess dialysis adequacy for every session without the need for repeated blood sampling.

Keywords: Hemodialysis, Adequacy, Online clearance monitoring, spKt/V